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Lab-in-a-trench platform for real-time monitoring of cell surface protein expression

Dimov, Ivan K. and Kijanka, Gregor and Ducrée, Jens (2010) Lab-in-a-trench platform for real-time monitoring of cell surface protein expression. In: MEMS 2010 - 23rd IEEE International Conference on Micro Electro Mechanical Systems, 24-28 January 2010, Wanchai, Hong Kong. ISBN 978-1-4244-5763-2

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Abstract

In this work we for the first time demonstrate real-time monitoring of the expression of membrane proteins in native, live cells, free of hydrodynamic stress at single cell resolution. This micro-optofluidic mechanism is uniquely enabled by the intricate interplay of gravity induced sedimentation with laminar flow, fast diffusion and short optical path length on our lab-in-a-trench platform.

Item Type:	Conference or Workshop Item (Paper)
Event Type:	Conference
Refereed:	Yes
Uncontrolled Keywords:	bioMEMS; biomembranes; cellular biophysics; lab-on-a-chip; proteins;
Subjects:	Biological Sciences > Microfluidics
DCU Faculties and Centres:	Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI) Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Published in:	Proceedings of the 23rd IEEE International Conference on Micro Electro Mechanical Systems. . Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-5763-2
Publisher:	Institute of Electrical and Electronics Engineers
Official URL:	http://dx.doi.org/10.1109/MEMSYS.2010.5442556
Copyright Information:	©2010 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Funders:	Science Foundation Ireland
ID Code:	15457
Deposited On:	14 Jul 2010 14:48 by DORAS Administrator. Last Modified 14 Jul 2010 14:48

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