Lab-in-a-trench platform for real-time monitoring of cell surface protein expression
Dimov, Ivan Krastev, Kijanka, Gregor and Ducrée, JensORCID: 0000-0002-0366-1897
(2010)
Lab-in-a-trench platform for real-time monitoring of cell surface protein expression.
In: MEMS 2010 - 23rd IEEE International Conference on Micro Electro Mechanical Systems, 24-28 January 2010, Wanchai, Hong Kong.
ISBN 978-1-4244-5763-2
In this work we for the first time demonstrate real-time monitoring of the expression of membrane proteins in native, live cells, free of hydrodynamic stress at single cell resolution. This micro-optofluidic mechanism is uniquely enabled by the intricate interplay of gravity induced sedimentation with laminar flow, fast diffusion and short optical path length on our lab-in-a-trench platform.
Proceedings of the 23rd IEEE International Conference on Micro Electro Mechanical Systems.
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Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-5763-2