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Droplet mixer based on siphon-induced flow discretization and phase shifting

Burger, Robert and Reis, N. and Fonseca, J. G. and Ducrée, Jens (2009) Droplet mixer based on siphon-induced flow discretization and phase shifting. In: MEMS 2009 - 22nd IEEE International Conference on Micro Electro Mechanical Systems, 25-29 January 2009 , Sorrento, Italy. ISBN 978-1-4244-2978-3

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We present a novel mixing principle for centrifugal microfluidic platforms. Siphon structures are designed to disrupt continuous flows in a controlled manner into a sequence of discrete droplets, displaying individual volumes as low as 60 nL. When discrete volumes of different liquids are alternately issued into a common reservoir, a striation pattern of alternating liquid layers is obtained. In this manner diffusion distances are drastically decreased and a fast and homogeneous mixing is achieved. Efficient mixing is demonstrated for a range of liquid combinations of varying fluid properties such as aqueous inks or saline solutions and human plasma. Volumes of 5 muL have been mixed in less than 20 s to a high mixing quality. One-step dilutions of plasma in a standard phosphate buffer solution up to 1:5 are also demonstrated.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Subjects:Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Published in:Proceedings of the 22nd IEEE International Conference on Micro Electro Mechanical Systems. . Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-2978-3
Publisher:Institute of Electrical and Electronics Engineers
Official URL:
Copyright Information:©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
ID Code:15459
Deposited On:14 Jul 2010 14:46 by DORAS Administrator. Last Modified 02 Feb 2015 15:47

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