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Hybrid integrated platform of PDMS microfluidics and silica capillary for effective CE and ESI-MS coupling

Dimov, Ivan Krastev and Riaz, Asif and Ducrée, Jens and Lee, Luke P. (2009) Hybrid integrated platform of PDMS microfluidics and silica capillary for effective CE and ESI-MS coupling. In: TRANSDUCERS 2009 - International Solid-State Sensors, Actuators and Microsystems Conference, 21-25 June 2009, Denver, USA. ISBN 978-1-4244-4193-8

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We present an effective hybrid integration of PDMS microfluidic devices and fused silica capillaries. These hybrid microfluidic integrated PDMS and silica capillary (iPSC) modules exhibit a novel architecture and method for leakage free CE sample injection requiring only a single high voltage source. Use of the iPSC devices is based on a modular approach which allows the capillary to be reused over 1,000 times whilst replacing the fluidics below it for different experiments. Integrating fused silica capillaries with PDMS microfluidics allows the direct application of a wide variety of well established conventional CE protocols for complex analyte separations and ESI-MS coupling, allowing users to focus on the sample analysis rather than the development of new separation protocols. The iPSC fabrication method is simple (3 steps) and quick (7 min).

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Uncontrolled Keywords:electrophoresis; ionisation; mass spectroscopy; micromechanical devices; silicon compounds;
Subjects:Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Published in:TRANSDUCERS 2009 - International Solid-State Sensors, Actuators and Microsystems Conference. . Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-4193-8
Publisher:Institute of Electrical and Electronics Engineers
Official URL:
Copyright Information:©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Funders:Science Foundation Ireland
ID Code:15461
Deposited On:14 Jul 2010 14:37 by DORAS Administrator. Last Modified 19 Dec 2016 10:27

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