TIR-based dynamic liquid-level and flow-rate sensing and its application on centrifugal microfluidic platforms
Hoffmann, J., Riegger, L., Mark, D., von Stetten, F., Zengerle, Roland and Ducrée, JensORCID: 0000-0002-0366-1897
(2009)
TIR-based dynamic liquid-level and flow-rate sensing and its application on centrifugal microfluidic platforms.
In: MEMS 2009 - 22nd IEEE International Conference on Micro Electro Mechanical Systems, 25-29 January 2009, Sorrento, Italy.
ISBN 978-1-4244-2978-3
For the first time we present a technique for the spatio-temporally resolved localization of liquid-gas interfaces on centrifugal microfluidic platforms based on total internal reflection (TIR) at the channel wall. The simple setup consists of a line laser and a linear image sensor array mounted in a stationary instrument. Apart from identifying the presence of (usually unwanted) gas bubbles, the here described online meniscus detection allows to measure liquid volumes with a high precision of 1.9%. Additionally, flow rates and viscosities (range: 1-10.7 mPa s) can be sensed even during rotation at frequencies up to 30 Hz with a precision of 4.7% and 4.3%, respectively.
Proceedings of the 22nd IEEE International Conference on Micro Electro Mechanical Systems.
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Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-2978-3