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Aliquoting structure for centrifugal microfluidics based on a new pneumatic valve

Mark, D. and Haeberle, S. and Metz, T. and Lutz, S. and Ducrée, Jens and Zengerle, R. and von Stetten, F. (2008) Aliquoting structure for centrifugal microfluidics based on a new pneumatic valve. In: MEMS 2008 - 21st International Conference on Micro Electro Mechanical Systems. ISBN 978-1-4244-1792-6

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Abstract

We present a new microvalve that can be monolithically integrated in centrifugally driven lab-on-a-chip systems. In contrast to existing operation principles that use hydrophobic patches, geometrically defined capillary stops or siphons, here we present a pneumatic principle. It needs neither additional local coatings nor expensive micro sized geometries. The valve is controlled by the spinning frequency and can be switched to be open when the centrifugal pressure overcomes the pneumatic pressure inside an unvented reaction cavity. We designed and characterized valves ranging in centrifugal burst pressure from 6700 Pa to 2100 Pa. Based on this valving principle we present a new structure for aliquoting of liquids. We experimentally demonstrated this by splitting 105 muL volumes into 16 aliquots with a volume CV of 3 %.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:lab-on-a-chip; microvalves;
Subjects:Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Published in:Proceedings of the 21st IEEE International Conference on Micro Electro Mechanical Systems. . Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-1792-6
Publisher:Institute of Electrical and Electronics Engineers
Official URL:http://dx.doi.org/10.1109/MEMSYS.2008.4443730
Copyright Information:©2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
ID Code:15465
Deposited On:14 Jul 2010 14:33 by DORAS Administrator. Last Modified 14 Jul 2010 14:33

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