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Alginate micro-bead fabrication on a centrifugal microfluidics platform

Haeberle, S. and Naegele, L. and Burger, R. and Zengerle, R. and Ducrée, Jens (2007) Alginate micro-bead fabrication on a centrifugal microfluidics platform. In: MEMS 2007 - 20th IEEE International Conference on Micro Electro Mechanical Systems, 21-25 January 2007 , Hyogo, Japan. ISBN 978-1-4244-0950-1

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Abstract

We present a novel method for the direct, centrifugally induced fabrication of small alginate beads displaying adjustable diameters between 180 mum and 800 mum by polymer-tube micronozzles. The size distribution features a CV of 7 - 16 % for the main peak. Up to 600 beads per second and channel are issued from the micronozzle through an air gap towards a standard lab tube ("Eppi") attached to the rotor spinning and containing a curing agent. At spinning frequencies between 5 Hz and 28 Hz, the tubes align horizontally under rotation and return to a vertical position as soon as the rotor is at rest. The hardened beads are collected within the tube for further processing or characterization. This method is considered as a low cost technology for micro encapsulation technologies.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:air gaps; nozzles;
Subjects:Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Published in:Proceedings of the 20th IEEE International Conference on Micro Electro Mechanical Systems (MEMS). . Institute of Electrical and Electronics Engineers. ISBN 978-1-4244-0950-1
Publisher:Institute of Electrical and Electronics Engineers
Official URL:http://dx.doi.org/10.1109/MEMSYS.2007.4433113
Copyright Information:©2007 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
ID Code:15468
Deposited On:14 Jul 2010 14:30 by DORAS Administrator. Last Modified 14 Jul 2010 14:30

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