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Optical beam guidance in monolithic polymer chips for miniaturized colorimetric assays

Grumann, M. and Moser, I. and Steigert, J. and Riegger, L. and Geipel, A. and Kohn, C. and Urban, G. and Zengerle, R. and Ducrée, Jens (2005) Optical beam guidance in monolithic polymer chips for miniaturized colorimetric assays. In: MEMS 2005 - 18th IEEE International Conference on Micro Electro Mechanical Systems, 30 January - 3 February 2005 , Miami, FL, USA. ISBN 0-7803-8732-5

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Abstract

For the first time, we present a simple and robust optical concept to enable precise and sensitive read-out of colorimetric assays in flat lab-on-a-chip devices. The optical guidance of the probe beam through an incorporated measurement chamber to the detector is based on the total internal reflection at V-grooves in the polymer chip. This way, the optical path length through the flat measurement chamber and thus the performance of the measurements are massively enhanced compared to direct (perpendicular) beam incidence. This is demonstrated by a chip-based, colorimetric glucose-assay on serum. Outstanding features are an excellent reproducibility (CV= 1.91 %), a competitive lower limit of detection (cmin = 124 μM), and a high degree of linearity (R2 = 0.998) within a working range extending over nearly three orders of magnitude.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:colorimetry; integrated optics; light reflection; optical polymers; substrates;
Subjects:Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Published in:Proceedings of the 18th IEEE International Conference on Micro Electro Mechanical Systems, 2005. . Institute of Electrical and Electronics Engineers. ISBN 0-7803-8732-5
Publisher:Institute of Electrical and Electronics Engineers
Official URL:http://dx.doi.org/10.1109/MEMSYS.2005.1453879
Copyright Information:©2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
ID Code:15474
Deposited On:14 Jul 2010 14:24 by DORAS Administrator. Last Modified 14 Jul 2010 14:24

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