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Direct hemoglobin measurement by monolithically integrated optical beam guidance

Grumann, M. and Dube, M. and Brefka, T. and Steigert, J. and Riegger, L. and Brenner, T. and Mittrnann, K. and Zengerle, R. and Ducrée, Jens (2005) Direct hemoglobin measurement by monolithically integrated optical beam guidance. In: TRANSDUCERS 2005 - 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 5-9 June 2005, Seoul, Korea. ISBN 0-7803-8994-8

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Abstract

We present a concept for optical beam guidance by total internal reflection (TIR) at V-grooves as retro reflectors which are monolithically integrated on a microfluidic "lab-on-a-disk". This way, the optical path length through a measurement chamber and thus the sensitivity of colorimetric assays is massively enhanced compared to direct (perpendicular) beam incidence. With this rugged optical concept, we determine the concentration of hemoglobin (Hb) in human whole blood. Outstanding features are a high degree of linearity (R2 = 0.993) between the optical signal and the Hb together with a reproducibility of CV= 2.9 %, and a time-to-result of 100 seconds, only.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:beam steering; biomedical measurement; blood; integrated optics; micro-optics; proteins;
Subjects:Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Published in:TRANSDUCERS 2005 - 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. . Institute of Electrical and Electronics Engineers. ISBN 0-7803-8994-8
Publisher:Institute of Electrical and Electronics Engineers
Official URL:http://dx.doi.org/10.1109/SENSOR.2005.1497269
Copyright Information:©2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
ID Code:15475
Deposited On:14 Jul 2010 14:22 by DORAS Administrator. Last Modified 14 Jul 2010 14:22

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