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TOPSPOT - a new method for the fabrication of microarrays

Ducrée, Jens and Gruhler, Holger and Hey, Nicolaus and Müller, Martin. and Bekesi, Stefan and Freygang, Michae and Sandmaiser, Hermann and Zengerle, Roland (2000) TOPSPOT - a new method for the fabrication of microarrays. In: MEMS 2000 - 13th IEEE Annual International Conference on Micro Electro Mechanical Systems, 23-27 January 2000, Miyazaki , Japan. ISBN 0-7803-5273-4

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This article outlines the new non-contact TOPSPOT method for printing microarrays in a highly parallelized fashion. It is based on a micromachined print head incorporating a central microarray of presently up to 96 vertical nozzles on the output side. Droplets featuring volumes down to 1nl aligned in a 500 μm grid are simultaneously ejected by applying a steep air pressure ramp to the open upper side of the liquid. Each of these nozzles is connected to a distinct fluidic reservoir constituting the interface to the macro world. To allow an automated replenishing of the chip, the alignment of the reservoirs is amenable for liquid handling via standard pipetting robots. Depending on the design of the print head, a maximum of 20 μl can be stored thus allowing one to dispend about 20.000 droplets of equal quality in a row. Besides its suitability for a robust biochip manufacturing facility in the laboratory, the print head is also well-integrable in a high-throughput production plant. These versions are scheduled to become commercially available in 2000.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Uncontrolled Keywords:arrays; biocontrol; drops; microactuators; microfluidics; nozzles;
Subjects:Biological Sciences > Biotechnology
Biological Sciences > Microfluidics
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Published in:Proceedings of the 13th IEEE Annual International Conference on Micro Electro Mechanical Systems. . Institute of Electrical and Electronics Engineers. ISBN 0-7803-5273-4
Publisher:Institute of Electrical and Electronics Engineers
Official URL:
Copyright Information:©2000 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
ID Code:15478
Deposited On:14 Jul 2010 14:18 by DORAS Administrator. Last Modified 25 Oct 2017 13:38

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