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Optically addressable single-use microfluidic valves by laser printer lithography

Gracia, Jose and Kurzbuch, Dirk and Benito-Lopez, Fernando and Diamond, Dermot and Lee, Luke and Ricco, Antonio (2010) Optically addressable single-use microfluidic valves by laser printer lithography. Lab on a Chip, 10 . pp. 2680-2687. ISSN 1473-0197

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Abstract

We report the design, fabrication, and characterization of practical optofluidic valves fabricated using laser printer lithography. Valves are opened by directing optical energy from a solid-state laser, with similar power characterisitcs to those used in CD/DVD drives, to a spot of printed toner where localized heating melts an orifice in the polymer layer in as little as 500 ms, connecting previously isolated fluidic components or compartments. Valve functionality, response time, and laser input energy dependence of orifice size are reported for cyclo-olefin copolymer (COC) and polyethylene terephthalate (PET) films. Implementation of these optofluidic valves is demonstrated on pressure-driven and centrifugal microfluidic platforms. In addition, these “one-shot” valves comprise a continuous polymer film that hermetically isolates on-chip fluid volumes within fluidic devices using low-vapor-permeability materials; we confirmed this for a period of one month. The fabrication and integration of optofluidic valves is compatible with a range of polymer microfabrication technologies and should facilitate the development of fully integrated, reconfigurable, and automated lab-on-a-chip systems, particularly when reagents must be stored on chip for extended periods, e.g. for medical diagnostic devices, lab-on-a-chip synthetic systems, or hazardous biochemical analysis platforms.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:polymer microfluidics, low-cost microfluidic systems, optically addressable microfluidics, optofluidics, laser printer lithography, single-use valves, one-shot valves.
Subjects:UNSPECIFIED
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Research Initiatives and Centres > CLARITY: The Centre for Sensor Web Technologies
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Publisher:Royal Society of Chemistry
Official URL:http://pubs.rsc.org/en/Content/ArticleLanding/2010/LC/c004980h
Copyright Information:© Royal Society of Chemistry 2010.
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland under Grant Nos. 05/CE3/B754 and 07/CE/I1147
ID Code:16151
Deposited On:11 May 2011 10:54 by Fernando Benito-Lopez. Last Modified 11 May 2011 11:03

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