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Ionic liquids for enzymatic sensing

Fraser, Kevin J. (2012) Ionic liquids for enzymatic sensing. In: Chemistry of Life: 243rd ACS meeting, 25-29 Mar 2012, San Diego.

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Point-of-care (POC) glucose biosensors play an important role in the management of blood sugar levels in patients with diabetes. One of the most commonly used enzymes in glucose biosensors is Glucose Oxidase (GOx). It is a biorecognition enzyme, which recognises the glucose molecule and acts as a catalyst to produce gluconic acid and hydrogen peroxide in the presence of glucose and oxygen. Ionic liquids (ILs) have evolved as a new type of solvent for biocatalysis, mainly due to their unique and tunable physical properties.[2] Amperometric biosensors employing ILs have been reported previously, for example, ([BMIM][BF4]) has been used as a mediator in a electrochemical H2O2 biosensor[3]. This interest is driven by the need to find molecular environments in which enzymes are highly stabilized while retaining redox activity; and in which substrate transport to, and product transport from, the enzyme is not inhibited In this work, we report the response characteristics of various enzymatic sensors (optical and electrochemical[4]) that incorporate RTIL’s as an integral part of their structure. Our results suggest that these sensing platforms can be incorporated into flexible materials such as carbon cloth and incorporated into wearable sensor platforms for monitoring important parameters related to athlete performance, and health.

Item Type:Conference or Workshop Item (Invited Talk)
Event Type:Conference
Uncontrolled Keywords:sensors
Subjects:Engineering > Materials
Physical Sciences > Chemistry
DCU Faculties and Centres:Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Research Initiatives and Centres > CLARITY: The Centre for Sensor Web Technologies
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Marie Curie Actions International Re-integration Grant (IRG) (PIRG07-GA-2010-268365) , Irish Research Council for Science, Engineering and Technology
ID Code:16873
Deposited On:10 Apr 2012 11:14 by Kevin Fraser. Last Modified 10 Apr 2012 11:14

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