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Novel low antimicrobial toxicity imidazolium ionic liquids: design, synthesis and their applications in organic synthesis

Gore, Rohitkumar G. (2012) Novel low antimicrobial toxicity imidazolium ionic liquids: design, synthesis and their applications in organic synthesis. PhD thesis, Dublin City University.

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Abstract

This thesis is focused on the synthesis and application of ionic liquids in organic synthesis. A library of novel imidazolium ionic liquids was designed and synthesised in efforts to find molecules which had reduced anti-microbial toxicity and increased aerobic biodegradation. Synthesis of novel ionic liquids has been carried with efficient and easy methods to achieve atom economy, reduced number of steps and high yields. Ionic liquids synthesized in the lab have been tested either as a catalyst in acetalization reactions, or as a solvent in Carbonyl-Ene reactions. These studies have given excellent results and clearly demonstrated the potential and applicability of ionic liquids in organic synthesis. Working with our collaborators, anti-microbial toxicity and biodegradation of these ionic liquids has been studied. Preliminary studies of the toxicity of all ionic liquids were performed against a panel of 12 fungi and 8 bacterial strains. Antifungal and antibacterial toxicity studies demonstrated that most of these ionic liquids did not inhibit the growth of any organism screened at concentrations of 2.0 mM. Biodegradation studies of the novel of novel ionic liquids have also been performed and have given valuable information on the next step in rational design towards novel readily biodegradable ionic liquids.

Item Type:Thesis (PhD)
Date of Award:November 2012
Refereed:No
Supervisor(s):Gathergood, Nicholas
Uncontrolled Keywords:Green Chemistry
Subjects:Physical Sciences > Environmental chemistry
Physical Sciences > Organic chemistry
Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
Funders:Environmental Protection Agency
ID Code:17469
Deposited On:21 Nov 2012 15:58 by Nick Gathergood. Last Modified 21 Nov 2012 15:58

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