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Centrifugally-driven sample extraction, preconcentration and purification in microfluidic compact discs

Vázquez, Mercedes and Brabazon, Dermot and Shang, Fengjun and Omamogho, Jesse O. and Glennon, Jeremy D. and Paull, Brett (2011) Centrifugally-driven sample extraction, preconcentration and purification in microfluidic compact discs. Trends in Analytical Chemistry, 30 (10). pp. 1575-1586. ISSN 0165-9936

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Abstract

Centrifugally driven micro-fluidic discs (µ-CDs) have attracted significant interest within the analytical science community over the last decade, primarily being focused on the potential of such platforms for performing parallel and/or multiplex biological assays and further application in biomedical diagnostics. More recently, µ-CD based devices have also been applied to environmental analysis as platforms for multi-sample extraction and transportation, prior to off-disc analysis in the laboratory. Therefore, this review critically summarises recent developments with µ-CD platforms for sample extraction, preconcentration, fractionation and purification in bioanalytical and environmental applications. In addition to also summarising the 10 common methods employed in the fabrication of µCD platforms, as applications of µ-CDs in sample extraction are generally based on enclosed series of extraction phases/micro-columns, the preparation of these stationary phases in micro-fluidic channels embedded in µ-CDs is also discussed.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Centrifugally-driven microextraction; Electrophoretic separation; Fractionation; Lab-on-a-disc; Microfluidic compact disc (μ-CD); Monolithic stationary phase; Packed stationary phase; Preconcentration; Purification; Sample extraction
Subjects:Physical Sciences > Analytical chemistry
DCU Faculties and Centres:Research Initiatives and Centres > Irish Separation Science Cluster (ISSC)
Publisher:Elsevier
Official URL:http://dx.doi.org/10.1016/j.trac.2011.07.007
Copyright Information:© 2011 Elsevier
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:20054
Deposited On:28 Jul 2014 11:39 by Shadi Karazi. Last Modified 14 Oct 2016 10:22

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