Laser-actuated centrifugo-pneumatic flow control towards ‘sample-to-answer’ integrated detection of multi-marker panels at the point-of-care
Mishra, Rohit and Reilly, Glen and Agnew, Matthew and Garvey, Alexander and Rogers, Ciaran and Andrade, Elaine and Ma, Hui and Fitzgerald, Sean and Zapatero, Julia and O'Kennedy, Richard and Ducrée, Jens (2018) Laser-actuated centrifugo-pneumatic flow control towards ‘sample-to-answer’ integrated detection of multi-marker panels at the point-of-care. In: The 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018), 21-25 Jan, 2018, Belfast, Northern Ireland. (In Press)
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Point-of-care diagnostics devices require user friendly automation of multi-step / multi-reagent bioanalytical protocols. We demonstrate, for the first time, Laser-actuated, Centrifugo-Pneumatic Valves (LCPVs) which open on-demand by ablating a remotely connected polymeric membrane with an instrument-based laser. Due to its small footprint, isolation of radiation-induced heating from the biological fluids and independence of radial position & contact-angle, the novel LCPV technology enables large–scale integration of flexibly customizable and operationally robust centrifugal microfluidic “Lab-on-a-Disc” (LoaD) systems. As a pilot application, we demonstrate the detection of Fatty Acid Binding Protein and Myeloperoxidase, both potential biomarkers used for cardiovascular disease (CVD) determination.
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