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Laser-actuated centrifugo-pneumatic flow control towards ‘sample-to-answer’ integrated detection of multi-marker panels at the point-of-care

Mishra, Rohit and Reilly, Glen and Agnew, Matthew and Garvey, Alexander and Rogers, Ciaran and Andrade, Elaine and Ma, Hui and Fitzgerald, Sean and Zapatero, Julia and O'Kennedy, Richard and Ducrée, Jens (2018) Laser-actuated centrifugo-pneumatic flow control towards ‘sample-to-answer’ integrated detection of multi-marker panels at the point-of-care. In: The 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018), 21-25 Jan, 2018, Belfast, Northern Ireland. ISBN ESSN: 2160-1968

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Abstract

Point-of-care diagnostics devices require user friendly automation of multi-step / multi-reagent bioanalytical protocols. We demonstrate, for the first time, Laser-actuated, Centrifugo-Pneumatic Valves (LCPVs) which open on-demand by ablating a remotely connected polymeric membrane with an instrument-based laser. Due to its small footprint, isolation of radiation-induced heating from the biological fluids and independence of radial position & contact-angle, the novel LCPV technology enables large–scale integration of flexibly customizable and operationally robust centrifugal microfluidic “Lab-on-a-Disc” (LoaD) systems. As a pilot application, we demonstrate the detection of Fatty Acid Binding Protein and Myeloperoxidase, both potential biomarkers used for cardiovascular disease (CVD) determination.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Cardiovascular Disease; MPO; FABP; POC detection; Sample-to-answer
Subjects:Physical Sciences > Analytical chemistry
Biological Sciences > Biotechnology
Biological Sciences > Microfluidics
Engineering > Biomedical engineering
Biological Sciences > Biosensors
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
DCU Faculties and Schools > Faculty of Science and Health > School of Physical Sciences
Published in:2018 IEEE 31th International Conference on Micro Electro Mechanical Systems (MEMS) , Proceedings. . IEEE Computer Society. ISBN ESSN: 2160-1968
Publisher:IEEE Computer Society
Official URL:https://doi.org/10.1109/MEMSYS.2018.8346774
Copyright Information:©2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland (SFI) under Grant No. 10/CE/B1821, SFI-TIDA 13/TIDA/B2692 and SFI-TIDA 14/TIDA/2264.
ID Code:22234
Deposited On:15 Feb 2018 16:22 by Rohit Mishra. Last Modified 11 May 2018 13:47

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