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Creatinine biosensors: principles and designs

Killard, Anthony J. and Smyth, Malcolm R. (2000) Creatinine biosensors: principles and designs. Trends in Biotechnology, 18 (10). pp. 433-437. ISSN 0167-7799

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Abstract

Creatinine biosensors, based on both potentiometric and amperometric devices, have been created. However, there are significant problems still to be addressed, including the balance between sensitivity and selectivity, interference rejection and sensor stability. In addition, many devices still rely on a dual-sensor approach for creatine and creatinine subtractive measurements. However, creatinine biosensors appear close to attaining the performance goals necessary for their widespread application. This article looks at the operating principle and design of both potentiometric and amperometric creatinine biosensors, and shows how the design of these devices affects their performance.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:review; biosensor; design; potentiometry; amperometry; sensitivity; selectivity; stability; electrodes; immobilized enzyme; creatinine;
Subjects:Biological Sciences > Biotechnology
Physical Sciences > Electrochemistry
Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > National Centre for Plasma Science and Technology (NCPST)
Publisher:Elsevier
Official URL:http://dx.doi.org/10.1016/S0167-7799(00)01491-8
ID Code:41
Deposited On:08 Nov 2006 by DORAS Administrator. Last Modified 30 Jan 2009 11:11

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