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Hypoxia helps glioma to fight therapy

Amberger-Murphy, Verena (2009) Hypoxia helps glioma to fight therapy. Current Cancer Drug Targets, 9 (3). pp. 381-390. ISSN 1568-0096

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Abstract

Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and anaplastic gliomas and 6 - 12 month for glioblastoma. Increasing malignancy of gliomas correlates with an increase in cellularity and a poorly organized tumour vasculature leading to insufficient blood supply, hypoxic areas and ultimately to the formation of necrosis, a characteristic of glioblastoma. Hypoxic/necrotic tumours are more resistant to chemotherapy and radiation. Hypoxia induces either directly or indirectly (through the activation of transcription factors) changes in the biology of a tumour and its microenvironment leading to increased aggressiveness and tumour resistance to chemotherapy and radiation. This review is focused on hypoxia-induced molecular changes affecting glioma biology and therapy.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:brain tumour; glioma; hypoxia; resistance; chemotherapy; radiotherapy;
Subjects:Medical Sciences > Cancer
DCU Faculties and Centres:Research Initiatives and Centres > National Institute for Cellular Biotechnology (NICB)
Publisher:Bentham Science Publishers
Official URL:http://dx.doi.org/10.2174/156800909788166637
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:4509
Deposited On:19 May 2009 16:10 by Verena Murphy. Last Modified 01 May 2010 04:02

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