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Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

Pellegrin, Yann and Neugebauer, Ute and Devocelle, Marc and Forster, Robert J. and Signac, William and Moran, Niamh and Keyes, Tia E. (2008) Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging. Chemical Communications, 2008 (42). pp. 5307-5309. ISSN 1364-548X

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Abstract

Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8). Both complexes exhibit long-lived, intense, and oxygen sensitive luminescence. (Ru-R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for premeablisation of the cell membrane. Such ruthenium polypyridyl peptide conjugates open up the possibility for targeted cell delivery for environmentally sensitive intensity and lifetime imaging.

Item Type:Article (Published)
Refereed:Yes
Subjects:Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Publisher:Royal Society of Chemistry
Official URL:http://dx.doi.org/10.1039/b810403d
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland
ID Code:4619
Deposited On:17 Jun 2009 13:38 by Ciaran McKenna. Last Modified 14 Nov 2009 04:02

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