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Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal carcinoma

Walsh, Naomi and Larkin, Anne-Marie and Kennedy, Susan and Connolly, Lisa and Ballot, Jo and Ooi, Wei and Gullo, Giuseppe and Crown, John and Clynes, Martin and O'Driscoll, Lorraine (2009) Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal carcinoma. BMC Urology, 9 (6). ISSN 1471-2490

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Abstract

Background: Renal cancer patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. Methods: The aim of this prospective study was to analyse by immunohistochemistry the expression of two of these transporter efflux pumps, namely MDR-1/P-gp (ABCB1) and MRP-1 (ABCC1) in archival material from 113 renal carcinoma patients. Results: In the largest study of its kind, results presented here show 100% of cases stained positively for P-gp and MRP-1 protein expression. Conclusion: However, although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:multidrug resistance; immunohistochemistry; renal cell carcinoma; cancer; MDR1/P-glycoprotein; multi drug resistance protein 1;
Subjects:Medical Sciences > Cancer
DCU Faculties and Centres:Research Initiatives and Centres > National Institute for Cellular Biotechnology (NICB)
Publisher:BioMed Central
Official URL:http://dx.doi.org/10.1186/1471-2490-9-6
Copyright Information:© 2009 Walsh et al.
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Ireland's Higher Educational Authority Programme for Research in Third Level Institutions (PRTLI) Cycle 3, Dublin City University's Faculty of Science and Health Targeted Research Initiative, Dublin City University's Research Fellowship
ID Code:4634
Deposited On:29 Jun 2009 09:32 by Naomi Walsh. Last Modified 22 Jul 2009 16:19

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