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Antibodies: production, functions and applications in biosensors

Killard, Anthony J. and Deasy, Brian and O'Kennedy, Richard and Smyth, Malcolm R. (1995) Antibodies: production, functions and applications in biosensors. TrAC Trends in Analytical Chemistry, 14 (6). pp. 257-266. ISSN 0165-9936

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Abstract

The antibody-antigen interaction is characterised by high affinity and high specificity, which makes it an excellent candidate as an analytical tool for selective and sensitive determinations. This biochemical interaction is being increasingly detected by solid-state physical transducers, in devices which are termed ‘biosensors’. The structure of the antibody molecule is central to its binding function. In addition, several techniques are available by which antibodies may be produced. An appreciation of both of these areas is essential in developing an immunosensor. The choice of the appropriate transducer is also important, and this short article also highlights some recent applications involving the use of electrochemical, optical, surface acoustic wave and semiconductor transducers.

Item Type:Article (Published)
Refereed:Yes
Subjects:Physical Sciences > Chemistry
Biological Sciences > Biosensors
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Publisher:Elsevier
Official URL:http://dx.doi.org/10.1016/0165-9936(95)91618-3
ID Code:58
Deposited On:08 Nov 2006 by DORAS Administrator. Last Modified 06 Mar 2009 13:56

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