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Protein immobilization on highly functional polymer grafted polyHIPEs

Audouin, Fabrice, Larragy, Ruth, O'Connor, Brendan orcid logoORCID: 0000-0002-6857-1614 and Heise, Andreas orcid logoORCID: 0000-0001-5916-8500 (2013) Protein immobilization on highly functional polymer grafted polyHIPEs. In: EPF 2013 European Polymer Congress, 16-21 Jun 2013, Pisa, Italy.

PolyHIPE have proven to be useful in a large variety of applications included column filtration/separation, supported organic chemistry, as media for tissue engineering and 3D cell culture.[1] We developed a new pHIPE platform by incorporation of a polymerizable monomer with amino group into the HIPE available for different post polymerizations.[2] The pHIPE with amino groups on the surface (pHIPE-NH2) can be directly used for the ring opening polymerization of amino acids N-carboxyanhydrates (NCAs) to obtain pHIPE-g- polypeptides or easily converted to an atom transfer radical polymerization (ATRP) initiator for activators generated electron transfer (AGET) ATRP of tert-butyl acrylate. The polymers grafted were deprotected to form or pHIPE-g-poly(acrylic acid) with reactive groups on the surface of the pHIPE, available for bioconjugation of fluorescent proteins such as enhanced green fluorescent protein (eGFP)
Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Subjects:Biological Sciences > Biotechnology
Physical Sciences > Analytical chemistry
Biological Sciences > Biochemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Research Institutes and Centres > Irish Separation Science Cluster (ISSC)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland
ID Code:17864
Deposited On:17 Jul 2013 11:06 by Brendan O'connor . Last Modified 18 Oct 2018 12:28

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