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Biopharmaceutical analysis - an investigation of the pharmacokinetic interaction between xipamide and triamterene when administered alone or in fixed combination

Caffrey, Edward (1988) Biopharmaceutical analysis - an investigation of the pharmacokinetic interaction between xipamide and triamterene when administered alone or in fixed combination. Master of Science thesis, Dublin City University.

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Abstract

A double blind placebo controlled, 4-way crossover study was carried out to investigate the pharmacokinetics of single oral doses of xipamide (lOmg), triamterene (30mg) and Trirexan <10mg xipamide + 30mg triamterene) in a group of 12 healthy male volunteers. HPLC assays were developed for the measurement of both drugs in plasma. Plasma levels of xipamide and triamterene were measured using these validated HPLC methods. The individual plasma level data are presented as tables and the mean plasma levels are presented graphically. Plasma xipamide levels measured over a 24 hour period after dosing with xipamide alone and in a fixed combination as Trirexan were analysed using the JANA curve stripping program. The estimates of the pharmacokinetic parameters thus obtained were then used in curve fitting analysis using an IBM-PC compatible version of NONLIIT 84. Plasma triamterene levels after dosing with triamterene and Trirexan were likewise analysed.

Item Type:Thesis (Master of Science)
Date of Award:1988
Refereed:No
Supervisor(s):Dadgar, Dariosh
Uncontrolled Keywords:Biopharmaceuticals; pharmacokinetic properties
Subjects:Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
ID Code:19154
Deposited On:23 Aug 2013 11:17 by Celine Campbell . Last Modified 23 Aug 2013 11:17

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