In this paper, I will show how molecular photoswitches can be used to provide key functions for microfluidic systems. In particular, I will focus on the optimisation of effects such as the actuation behaviour of hydrogels incorporating spiropyran derivatives, and the potential impact of these advances on the entire area of microfluidics. In addition, I will also summarise recent developments in photo-chemo-propulsion of micro-droplets in fluidic channels.