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Reciprocating, buoyancy-driven radial pumping on centrifugal microfluidic platforms

Kilcawley, Niamh, Kinahan, David J. ORCID: 0000-0003-1968-2016, Kernan, David and Ducrée, Jens ORCID: 0000-0002-0366-1897 (2014) Reciprocating, buoyancy-driven radial pumping on centrifugal microfluidic platforms. In: 4th European Conference on Microfluidics, 10-12 Dec 2014, Limerick, Ireland.

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Abstract

Centrifugal microfluidic systems bear great potential for applications where ruggedness, portability, ease-of-use, and cost efficiency are critical. However, due to the unidirectional nature of the centrifugal pumping force, the number of sequential process steps which can be integrated on these “Lab-on-a-Disc” (LoaD) devices is limited by their finite radial extension. To significantly widen this bottleneck and thus expand the scope of applications that can be ported on these LoaD platforms, various groups have developed a range of centripetal pumping mechanisms. Here, we present two advancements over our previous efforts in this area by combining buoyancy-based pumping with dissolvable film (DF) valves. First, we present a buoyancy-driven, reciprocating flow of a dense liquid initially located an upper reservoir and a sample in a peripheral reservoir. Secondly, we combine buoyancy-driven centripetal pumping with sample discretization and metering to fully integrate and automate a liquid handling protocol towards implementing a multi-parameter bioassay on a disc.

Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Centripetal Pumping; Centrifugal Microfluidics; Multiphase Liquids; Metering; Bio-Assay
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:20341
Deposited On:18 Dec 2014 11:38 by David Kinahan . Last Modified 26 Oct 2018 10:12

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