This paper explores the potential for using Brain Computer Interfaces (BCI) as a relevance feedback mechanism in contentbased image retrieval. Several experiments are performed using a rapid serial visual presentation (RSVP) of images at different rates (5Hz and 10Hz) on 8 users with different degrees of familiarization with BCI and the dataset. We compare the feedback from the BCI and mouse-based interfaces in a subset of TRECVid images, finding that, when users have limited time to annotate the images, both interfaces are comparable in performance. Comparing our best users in a retrieval task, we found that EEG-based relevance feedback can outperform mouse-based feedback.