With population growth, there is an ever-increasing requirement for fresh-water sources and safe, ‘toxin-free’ shellfish and fish stocks. To monitor these resources carefully, there is a need for the development of an in-situ algal-toxin monitoring solutions. Presented here is one of these solutions; The ToxiSense Detection system (Figure 1). This system has been designed to be as generically applicable to toxin detection as possible, with the cyanobacterial Microcystin-LR used for proof-of-concept.