Disc-embedded grinding mill towards process integtrated hydro-mechanical cell lysis on centrifugal microfluidic platforms
Gaughran, JenniferORCID: 0000-0002-3659-036X, Kelly, Robert, Kinahan, David J.ORCID: 0000-0003-1968-2016 and Ducrée, JensORCID: 0000-0002-0366-1897
(2016)
Disc-embedded grinding mill towards process integtrated hydro-mechanical cell lysis on centrifugal microfluidic platforms.
In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 9-13 Oct 2016, Dublin, Ireland.
ISBN 978-0-9798064-9-0
For the first time we utilize the spindle motor intrinsic to centrifugal microfluidic systems to drive a grinding mill for cell lysis in a stator-rotor concept. This mechanical concept particularly enables the lysis of armored cells and, as a further benefit, avoids the addition of chemicals that potentially inhibit subsequent reactions. As a proof of concept we demonstrate the lysis of the silica-shelled algae Phaeodactylum Tricornutum.
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Funders:
Programme for Research in Third Level Institutions (PRTLI) Cycle 5. The PRTLI is co-funded through the European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme 2007-2013.
ID Code:
21440
Deposited On:
20 Oct 2016 10:50 by
David Kinahan
. Last Modified 01 Mar 2021 15:27