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Validating a novel web-based method to capture disease progression outcomes in multiple sclerosis

Leddy, Sara ORCID: 0000-0002-5249-6234, Hadavi, Shahrzad, McCarren, Andrew ORCID: 0000-0002-7297-0984, Giovannoni, Gavin ORCID: 0000-0001-9995-1700 and Dobson, Ruth ORCID: 0000-0002-2993-585X (2013) Validating a novel web-based method to capture disease progression outcomes in multiple sclerosis. Journal of Neurology, 260 (10). pp. 2505-2510. ISSN 1432-1459

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Abstract

The Expanded Disability Status Scale (EDSS) is the current ‘gold standard’ for monitoring disease severity in multiple sclerosis (MS). The EDSS is a physician-based assessment. A patient-related surrogate for the EDSS may be useful in remotely capturing information. Eighty-one patients (EDSS range 0–8) having EDSS as part of clinical trials were recruited. All patients carried out the web-based survey with minimal assistance. Full EDSS scores were available for 78 patients. The EDSS scores were compared to those generated by the online survey using analysis of variance, matched pair test, Pearson’s coefficient, weighted kappa coefficient, and the intra-class correlation coefficient. The internet-based EDSS scores showed good correlation with the physician-measured assessment (Pearson’s coefficient = 0.85). Weighted kappa for full agreement was 0.647. Full agreement was observed in 20 patients

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Multiple Sclerosis; EDSS; Functional System; Disability Assessment; Internet
Subjects:Biological Sciences > Neuroscience
DCU Faculties and Centres:UNSPECIFIED
Publisher:Springer Verlag
Official URL:http://dx.doi.org/10.1007/s00415-013-7004-1
Copyright Information:© 2013 Springer
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:24397
Deposited On:30 Apr 2020 09:44 by Andrew Mccarren . Last Modified 30 Apr 2020 14:33

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