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Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential

Matsiko, Amos ORCID: 0000-0003-4740-5489, Levingstone, Tanya J. ORCID: 0000-0002-9751-2314, Gleeson, John P. ORCID: 0000-0003-2917-6758 and O'Brien, Fergal J. ORCID: 0000-0003-2030-8005 (2015) Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. Advanced Healthcare Materials, 4 (8). pp. 1175-1179. ISSN 2192-2640

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Abstract

Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen–hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Articular Cartilage; Collagen-based Scaffolds; Transforming Growth Factor-Beta 3; Growth Factor Delivery; Mesenchymal Stem Cells
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Publisher:Wiley
Official URL:https://dx.doi.org/10.1002/adhm.201500053
Copyright Information:© 2015 Wiley
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Enterprise Ireland, Proof of Concept PC/2007/331, Commercialization Fund Technology Development Phase CFTD/2009/0104
ID Code:27286
Deposited On:01 Jun 2022 12:11 by Thomas Murtagh . Last Modified 10 Jan 2023 15:05

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