Matsiko, Amos 
ORCID: 0000-0003-4740-5489, Levingstone, Tanya J. ORCID: 0000-0002-9751-2314, Gleeson, John P. ORCID: 0000-0003-2917-6758 and O'Brien, Fergal J. ORCID: 0000-0003-2030-8005
(2015)
Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
Advanced Healthcare Materials, 4
(8).
pp. 1175-1179.
ISSN 2192-2640
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Abstract
Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen–hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.
| Item Type: | Article (Published) |
|---|---|
| Refereed: | Yes |
| Uncontrolled Keywords: | Articular Cartilage; Collagen-based Scaffolds; Transforming Growth Factor-Beta 3; Growth Factor Delivery; Mesenchymal Stem Cells |
| Subjects: | Engineering > Biomedical engineering |
| DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering |
| Publisher: | Wiley |
| Official URL: | https://dx.doi.org/10.1002/adhm.201500053 |
| Copyright Information: | © 2015 Wiley |
| Use License: | This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License |
| Funders: | Enterprise Ireland, Proof of Concept PC/2007/331, Commercialization Fund Technology Development Phase CFTD/2009/0104 |
| ID Code: | 27286 |
| Deposited On: | 01 Jun 2022 12:11 by Thomas Murtagh . Last Modified 10 Jan 2023 15:05 |
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