The post-Anthropocene era profoundly influences human beings, who need to develop new competencies and skills, among which creativity is one of the most important. Creativity, as the ability to generate a new and original outcome, is required to face complex social and sustainability challenges specific for an uncertain future; it can also help move towards a just and inclusive digital and green transformation. However, along with digital advancement, creativity transforms as well, acquiring new forms, and through design future methods can be channelled to play the role of a guiding value. We should start to ask ourselves how to expand the definition of creativity to make it more inclusive to non-human agents and rethink the values and ethics involved in its process. What new skills, methods and approaches do we need today to design for a more-than-human world? This chapter presents a framework that redefines creativity in the post-Anthropocene era from the authors’ perspectives, and foregrounds four relevant dimensions to keep in a dynamic balance: Regenerative Creativity, Digital Creativity, Ethics and Futures Thinking.