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Effect of self-regulated exercise intensity on endothelial function in men with coronary artery disease

Hughes, Sarah and McGuinness, Kevin and O'Connor, Noel E. and Furlong, Bróna and Gray, Cleona and O'Hara, Kevin and McCaffrey, Noel and O'Connor, Paul and Murphy, Ronan and Ross , Mark and Wekesa, Antony and Harrison, Michael and Moyna, Niall (2011) Effect of self-regulated exercise intensity on endothelial function in men with coronary artery disease. In: ACSM's 58th Annual Meeting, 31 May - 4 Jun 2011, Denver, Colorado.

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Background: Physiologically based exercise prescriptions normally involve identifying an intensity range that elicits a predetermined VO2 or heart rate. In many instances prescribed exercise that exceeds an individual’s preferred level of intensity may establish a negative attitude toward physical activity. Longitudinal studies report that participants tend to deviate from physiologically based prescribed levels of intensity in favour of their apparently preferred levels. Self-regulated exercise intensity may increase enjoyment and promote adherence by allowing individuals successfully complete an activity within their perceptual preference range and without undue physiological strain. The purpose of this study is to examine the effect of self-regulated exercise intensity on endothelial function (a validated surrogate measure of early atherosclerosis) in men with coronary artery disease. Methods: Eight men with coronary artery disease (65.7 ± 4.5 yr, VO2max 18.6 ± 4.1 ml/kg/min, BMI 29.7±3.3 kg/m-2) underwent 20 min of treadmill walking at a self-regulated intensity. Endothelial dependent dilation of the brachial artery was assessed before and 1 h following the acute bout of exercise. Vessel diameter was determined using high resolution vascular ultrasonography (SonoSite, MicroMaxx) from flow mediated dilation (FMD) following 5 min of forearm occlusion. Endothelial independent vasodilation was measured at min 3, min 4 and min 5 following the administration of glyceryl trinitrate (0.4 mg). Results: The subjects self-selected an average treadmill walking speed of 5.3 km/h and a grade of 0.7%. This intensity equated to 65.7% VO2max, and an RPE-O of 12.0. Compared to baseline, FMD was significantly increased (1 min (4.6 v 10.7%) and 3 min (6.2 v 11.0) post occlusion) at 60 min following the acute bout of self regulated exercise. There was no change in endothelial independent dilation in response to the acute bout of exercise. Conclusion: These results indicate a beneficial effect of self-regulated exercise on endothelial dependent vascular function in men with coronary artery disease.

Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Uncontrolled Keywords:coronary artery disease; CAD
Subjects:Medical Sciences > Exercise
Medical Sciences > Sports sciences
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Electronic Engineering
DCU Faculties and Schools > Faculty of Science and Health > School of Health and Human Performance
Research Initiatives and Centres > CLARITY: The Centre for Sensor Web Technologies
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland
ID Code:16319
Deposited On:19 Jul 2011 09:40 by Noel Edward O'Connor. Last Modified 10 Feb 2017 14:36

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