Browse DORAS
Browse Theses
Search
Latest Additions
Creative Commons License
Except where otherwise noted, content on this site is licensed for use under a:

PECVD of silicon and titanium based coatings to enhance the biocompatibility of blood contacting biomedical devices

Gandhiraman, Ram Prasad (2007) PECVD of silicon and titanium based coatings to enhance the biocompatibility of blood contacting biomedical devices. PhD thesis, Dublin City University.

Full text available as:

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
8Mb

Abstract

The clinical success of a surgical implantation depends on various factors including the design and biocompatibility of the biomaterial, surgical procedure adopted, injuries made during implantation and health and condition of the patient. The success of a biomaterial depends on the interaction and the progressive reaction between the blood components and the surface of the implant. Proteins present in the blood will be the first components to become adsorbed on the surface of the biomaterial. Studies show that the protein fibrinogen present in the blood plasma is the major initiator of inflammatory reactions and involved in blood clotting. By minimizing the fibrinogen adsorption it is possible to reduce the contribution of the biomaterial surface characteristics to thrombosis and inflammatory reactions. In this work, silicon and titanium based thin film coatings with four different surface characteristics were deposited by PECVD on 316L stainless steel substrates. Polymer-like SiOxCyHz, silica-like SiOx, titanium oxide TiO, and silicon-titanium mixed oxide coatings were deposited by plasma decomposition of organic molecules. An extensive study was done on silicon based coatings deposited from hexamethyl disiloxane (HMDSO) to analyze the influence of plasma process parameters like RF power, precursor flow ratio and flow rate on the surface chemical and mechanical characteristics of the film. Titanium dioxide coatings deposited from titanium tetraisopropoxide (TIP) were also analyzed for the effect of plasma process parameters on their surface characteristics. Silicon - titanium mixed oxide coatings were deposited to obtain intermediate characteristics between silicon oxide and titanium oxide films and the process was optimized to get a hydrophilic surface with wettability lower than SiO, and a bandgap higher than that of titanium dioxide. It was concluded, from the fibrinogen adsorption studies, that both the film wettability and bandgap has to be optimized in order to minimize the fibrinogen adsorption.

Item Type:Thesis (PhD)
Date of Award:2007
Refereed:No
Supervisor(s):Daniels, Stephen and Cameron, David
Uncontrolled Keywords:biomaterials; fibrinogen; inflammatory reactions; coatings
Subjects:Engineering > Materials
Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Electronic Engineering
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
ID Code:17008
Deposited On:15 May 2012 11:32 by Fran Callaghan. Last Modified 15 May 2012 11:32

Download statistics

Archive Staff Only: edit this record