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Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease

Doggett, Anita (2006) Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease. Master of Science thesis, Dublin City University.

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Abstract

Title: Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease. Purpose: This study examined the effects of a non-invasive ventilator on submaximal and maximal exercise performance in patients with chronic obstructive pulmonary disease (COPD). Methods: Fourteen men (66.0 ± 7.4yr) and six women (59.0 ± 7.4yr) with a diagnosis of COPD, a forced expiratory volume! (FEVi) <40%, and the ability to tolerate 12 cmH20 of pressure on a non- invasive ventilator performed two maximal exercise tests on a cycle ergometer, with and without ventilatory assistance prior to exercise. Blood samples, respiratory metabolic measures, heart rate and rating of perceived exertion (RPE) were obtained throughout each exercise test. Results: Peak work rate (W), total exercise time, and respiratory rate were higher (p<0.05) when exercise was preceded by ventilatory support compared to no support. There was no difference in peak oxygen uptake (V02), carbon dioxide (VC02,), heart rate (HR), minute ventilation (VE), tidal volume (VT), blood lactate or RPE between the two experimental conditions. A total of 12 subjects completed at least 5 stages of the exercise protocol, and their physiological response during exercise with NIV and without NIV were compared. RPE was significantly lower during the first 3 min in the NIV condition than the no NIV condition. Circulating levels of blood lactate were lower (p<0.01) during stage 3 in the NIV than the than no NIV condition. There was no difference in RR, VT, HR, %HR, VE, V 0 2and %V02 between the two experimental conditions during sub maximal exercise. Conclusions: Application of non-invasive ventilatory support prior to exercise improves maximal exercise performance, but has no effect on cardio-metabolic response during submaximal exercise in patients with COPD.

Item Type:Thesis (Master of Science)
Date of Award:2006
Refereed:No
Supervisor(s):Moyna, Niall
Uncontrolled Keywords:inspiratory pressure support; chronic obstructive pulmonary disease; COPD
Subjects:Medical Sciences > Performance
Medical Sciences > Exercise
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Health and Human Performance
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
ID Code:17202
Deposited On:17 Aug 2012 14:44 by Fran Callaghan. Last Modified 17 Aug 2012 14:44

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