The aim of the SCHEMA Network of Excellence is to bring together a critical mass of universities, research centers, industrial partners and end users, in order to design a reference system for content-based semantic scene analysis, interpretation and understanding. Relevant research areas include: content-based multimedia analysis and automatic annotation of semantic multimedia content, combined textual and multimedia information retrieval, semantic -web, MPEG-7 and MPEG-21 standards, user interfaces and human factors. In this paper, recent advances in content-based analysis, indexing and retrieval of digital media within the SCHEMA Network are presented. These advances will be integrated in the SCHEMA module-based, expandable reference system.