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The Holland broadcast language and the modeling of biochemical networks

Decraene, James and Mitchell, George G. and McMullin, Barry and Kelly, Ciaran (2007) The Holland broadcast language and the modeling of biochemical networks. In: EuroGP 2007: the 10th European Conference of Genetic Programming, 11-13 April 2007, Valencia, Spain. ISBN 978-3-540-71602-0

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Abstract

The Broadcast Language is a programming formalism devised by Holland in 1975, which aims at improving the efficiency of Genetic Algorithms (GAs) during long-term evolution. The key mechanism of the Broadcast Language is to allow GAs to employ an adaptable problem representation. Fixed problem encoding is commonly used by GAs but may limit their performance in particular cases. This paper describes an implementation of the Broadcast Language and its application to modeling biochemical networks. Holland presented the Broadcast Language in his book “Adaptation in Natural and Artificial Systems” where only a description of the language was provided, without any implementation. Our primary motivation for this work was the fact that there is currently no published implementation of the Broadcast Language available. Secondly, no additional examination of the Broadcast Language and its applications can be found in the literature. Holland proposed that the Broadcast Language would be suitable for the modeling of biochemical models. However, he did not support this belief with any experimental work. In this paper, we propose an implementation of the Broadcast Language which is then applied to the modeling of a signal transduction network. We conclude the paper by proposing that with some refinements it will be possible to use the Broadcast Language to evolve biochemical networks in silico.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Additional Information:The original publication is available at www.springerlink.com
Uncontrolled Keywords:Broadcast Language; adaptable representation; biochemical networks modeling;
Subjects:Computer Science > Artificial intelligence
Computer Science > Algorithms
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Electronic Engineering
Research Initiatives and Centres > Research Institute for Networks and Communications Engineering (RINCE)
Published in:Genetic Programming. Proceedings of the 10th European Conference of Genetic Programming. Lecture Notes in Computer Science 4445. Springer. ISBN 978-3-540-71602-0
Publisher:Springer
Official URL:http://dx.doi.org/10.1007/978-3-540-71605-1_34
Copyright Information:© Springer 2007
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:4599
Deposited On:08 Jun 2009 14:28 by James Decraene. Last Modified 08 Jun 2009 14:28

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