Textiles are ubiquitous to us, enveloping our skin and surroundings. Not only do they provide a protective shield or act as a comforting cocoon but they also serve esthetic appeal and cultural importance. Recent technologies have allowed the traditional functionality of textiles to be extended. Advances in materials science have added intelligence to textiles and created ‘smart’ clothes. Smart textiles can sense and react to environmental conditions or stimuli, e.g., from mechanical, thermal, chemical, electrical, or magnetic sources (Lam Po Tang and Stylios 2006). Such textiles find uses in many applications ranging from military and security to personalized healthcare, hygiene, and entertainment. Smart textiles may be termed ‘‘passive’’ or ‘‘active.’’ A passive smart textile monitors the wearer’s physiology or the environment, e.g., a shirt with in-built thermistors to log body temperature over time. If actuators are integrated, the textile becomes an active, smart textile as it may respond to a particular stimulus, e.g., the temperature-aware shirt may automatically roll up the sleeves when body temperature rises. The fundamental components in any smart textile are sensors and actuators. Interconnections, power supply, and a control unit are also needed to complete the system. All these components must be integrated into textiles while still retaining the usual tactile, flexible, and comfortable properties that we expect from a textile. Adding new functionalities to textiles while still maintaining the look and feel of the fabric is where nanotechnology has a huge impact on the textile industry. This article describes current developments in materials for smart nanotextiles and some of the many applications where these innovative textiles are of great benefit.