Walshe, Alan (2003) Immune responses to Fasciola hepatica infection, and Fasciola hepatica derived antigens. Master of Science thesis, Dublin City University.
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Abstract
The aim of this study was to investigate immune responses as a result of infection with the parasitic helminth, Fasciola hepatica. Analysis of IL-4 and Interferon-y cytokines described a predominant type 2 immune response in BALB/c mice infected with metacercana of F hepatica Levels of IL-4 mRNA assessed by reverse transcnption-polymerase chain reaction (RT-PCR) provide the first evidence that the immune response becomes polarised 1 day post infection. We also investigated immune responses to F hepatica derived antigens IL-4 and Interferon-y cytokine production revealed a polarised type 2 response m BALB/c mice immunised with F hepatica excretory/secretory (ES) products. As type 1 immune responses have been associated with protection against infection with F hepatica (Mulcahy et a l , 1998), we established a polarised type 1 immune response in BALB/c mice by immunising with cathepsm L in combination with various adjuvants.
| Item Type: | Thesis (Master of Science) |
|---|---|
| Date of Award: | 2003 |
| Refereed: | No |
| Supervisor(s): | O'Neill, Sandra |
| Uncontrolled Keywords: | Fasciola hepatica; Antigen-antibody reactions; Liver flukes; Immune response |
| Subjects: | Biological Sciences > Biotechnology |
| DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology |
| Use License: | This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License |
| ID Code: | 18265 |
| Deposited On: | 27 May 2013 13:53 by Celine Campbell . Last Modified 27 May 2013 13:53 |
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