1) Monoclonal antibodies directed against both Factor FVIII procoagulant protein (FVIII C) and fibrinogen were produced and characterised. 2) Polyclonal antisera directed against a BSA-diazepam conjugate was produced These were found to be directed against the conjugate rather than diazepam. 3) IB vitro studies on the effects of both coumarin and 7 -hydroxycoumarin on the growth of cells indicated that neither drug was cytotoxic, but they both slowed the growth of cells in vitro 7-hydroxycoumarm was found to have more potent cytostatic effects than coumarin. 4) The results from a clinical study on the effects of coumarin on liver function indicated that 0 36% of patients experienced an idiosyncratic hepatotoxicity to coumarin.