CD4 cell isolation from blood using finger-actuated on-chip magnetophoresis for rapid HIV/AIDS diagnostics
Glynn, MacdaraORCID: 0000-0002-6347-4348, Kinahan, David J.ORCID: 0000-0003-1968-2016, Chung, Danielle and Ducrée, JensORCID: 0000-0002-0366-1897
(2014)
CD4 cell isolation from blood using finger-actuated on-chip magnetophoresis for rapid HIV/AIDS diagnostics.
In: 27th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2014), 26-30 Jan 2014, San Francisco, CA..
With timely diagnosis and correct treatment, people living with HIV/AIDS can consider the disease as a chronic rather than a terminal illness. Still, in regions were HIV is endemic, rapid diagnosis is a challenge due to the complexity of the instrumentation required, the poor infrastructure in these countries, as well as the technical expertise required to carry out the diagnosis. This paper presents a microfluidic chip based approach allowing semi-quantitative CD4+ cell coun¬ting on a cheap, rapid, highly portable and instrumentation-free Point-of-Care HIV diagnostic device. Flow is driven by finger-pressing a flexible reservoir, and the target cells are immobilized through magnetophoresis. The fluidic test completes within ca. 30 seconds of sample application to the chip.
Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on. IEEE Conferences
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Institute of Electrical and Electronic Engineers.