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Effect of hydroxyapatite on biodegradable scaffolds fabricated by SLS

Eosoly, Szilvia, Lohfeld, Stefan and Brabazon, Dermot orcid logoORCID: 0000-0003-3214-6381 (2008) Effect of hydroxyapatite on biodegradable scaffolds fabricated by SLS. Key Engineering Materials, 396-39 . pp. 659-662. ISSN 1013-9826

Abstract
Selective laser sintering (SLS) has the potential to fabricate bioresorbable polymer / ceramic composite scaffolds with pre-designed external and internal architecture that can be used for bone tissue engineering applications. Scaffolds were fabricated using poly-c-caprolactone as the base material. The effect of 15 and 30 wt% of hydroxyapatite (HA) addition was investigated in terms of compressive properties, accuracy, surface topology, and wettability. Fabricated dimensions of PCL microstructures showed great deviations from their nominal values. Average surface roughness was found to be Ra=25±4 gm. Increased HA content had no statistically significant effect on accuracy and surface roughness. However the addition of HA had a significant influence on compressive properties, hydrophobicity and wettability of the samples. Addition of 30 wt% HA improved initial compressive modulus of pure PCL scaffolds from 1.31±0.08 MPa to 1.58±0.18 MPa. Yield strength values increased from 0.14±0.07 MPa to 0.17±0.01 MPa by adding 15 wt% of HA, but decreased with further HA addition. Yield strain for all compositions was over c=0.06. Increased HA content decreased hydrophobicity and increased wettability of scaffold surfaces. The study demonstrated the ability of SLS to fabricate tissue engineering scaffolds, and the positive effect of HA particle reinforcement in terms of compressive mechanical properties and surface characteristics.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Bone Scaffold; Hydroxyapatite (HAP); Poly(ε-caprolactone); Selective Laser Sintering (SLS)
Subjects:Engineering > Materials
Engineering > Mechanical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Publisher:Scientific.net
Official URL:http://dx.doi.org/10.4028/www.scientific.net/KEM.3...
Copyright Information:© 2008 Scientific.net
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:20351
Deposited On:19 Dec 2014 11:35 by Fran Callaghan . Last Modified 20 Sep 2018 10:29
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