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Association between essential trace and toxic elements in scalp hair samples of smokers rheumatoid arthritis subjects

Afridi, Hassan Imran, Gul Kazi, Tasneem, Brabazon, Dermot orcid logoORCID: 0000-0003-3214-6381 and Naher, Sumsun orcid logoORCID: 0000-0003-2047-5807 (2011) Association between essential trace and toxic elements in scalp hair samples of smokers rheumatoid arthritis subjects. Science of the Total Environment, 412-41 . pp. 93-100.

The incidence of rheumatoid arthritis (RA) has been increased among people who possess habit of tobacco smoking. In the present study, zinc (Zn), copper (Cu), manganese (Mn), lead (Pb) and cadmium (Cd) were determined in scalp hair samples of smokers and nonsmokers RA patients, residents of Dublin, Ireland. For comparison purposes scalp hair samples of age and sex matched healthy smokers and nonsmokers were also analyzed. The concentrations of understudied elements were measured by inductive coupled plasma atomic emission spectrophotometer, prior to microwav e assisted acid digestion. The validity and accuracy of methodology was checked using certified reference material (NCS ZC 81002b) and by the conventional wet acid digestion method on the same certified reference material and on real samples. The mean hair Zn, Cu and Mn contents were significantly lower in smokers and nonsmokers RA patients as compared to healthy individuals (p = 0.01 - 0.001). Whereas the concentrations of Cd and Pb were significantly higher in scalp hair samples of RA patients of both group (p <0.001). The referent smokers have high level of Cd and Pb in their scalp hair samples as compared to those had not smoking tobacco (p <0.01). The ratio of Cd and Pb to Zn, Cu and Mn in scalp hair samples was also calculated. The Cd/Zn ratio was higher in smoker RA patients with related to nonsmoker RA and referents. This study is compelling evidence in support of positive associations between toxic elements, cigarette smoking, deficiency of essential trace elements and risk of arthritis.
Item Type:Article (Published)
Uncontrolled Keywords:Rheumatoid arthritis; Scalp hair; Cigarette smokers; Elements; Inductive coupled plasma atomic emission spectrophotometer
Subjects:Engineering > Materials
Engineering > Mechanical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Official URL:http://dx.doi.org/10.1016/j.scitotenv.2011.09.033
Copyright Information:© 2011 Elsevier
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:20468
Deposited On:06 Feb 2015 11:41 by Fran Callaghan . Last Modified 20 Sep 2018 09:52

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