By incorporating a set of membranes which selectively dissolve upon contact with aqueous or or-ganic solvents at strategic locations on a disc cartridge, we succeeded to fully automate the solid-phase extraction of nucleic acids by varying the spin rate of a low-cost spindle motor. A solvent- and phase-selective graphene oxide (GO) membrane governs the routing of flows to designated elution and waste chambers. The serial release of on-board sample and reagents is centrifugo-pneumatically controlled by our previously introduced, event-triggered valving scheme. The entire process of ex-traction completes in less than 8 minutes.