In today’s changing world, there is an ever-increasing demand and need for software reuse in applications, where the process model needs to be reused in different applications in a domain-specific environment. The process model is required to adapt and implement changes promptly at run-time, in response of the end-user configuration requirements. Furthermore, reusability is emerging strongly as a necessary underlying capability, particularly for customization of business in a dynamic environment where end-users can select their requirements to achieve a specific goal. Such adaptations are in general, performed by non-technical end-users which can lead to losing a significant number of person-days and which can also open up possibilities to introduce errors into the system. These scenarios call for - indeed cry out for - a system with a configurable and customizable business process, operable by users with limited technical expertise. Research aims to provide a framework for generating the rule language and configuring domain constraints. This framework builds upon the core idea of Software Product Lines Engineering (SPLE) and Model-Driven Architecture (MDA). The SPLE provides a platform that includes the variability model. Variability models offer features where end-users can select features and customize possible changes in the domain template, which is the container for domain and process models. The user selects their requirements as a feature from feature models and generates rules from domain models using MDA. Then, the generated rules are translated from a high-level domain model, based on the requirements of the end-user. On the other hand, the weaving model is responsible for reflecting activation and de-activation of features of variabilities in the domain template. The usability of the proposed framework is evaluated with a user study in the area of Digital Content Technology. The results demonstrate that usability improvements can be achieved by using the proposed techniques. The framework can be used to support semi-automatic configuration that is efficient, effective and satisfactory.