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Novel injectable gallium-based self-setting glass alginate hydrogel composite for cardiovascular tissue engineering

Clarkin, Owen ORCID: 0000-0001-6007-806X, Wu, Bing ORCID: 0000-0002-2739-5124, Cahill, Paul A. ORCID: 0000-0002-5385-6502, Brougham, Dermot F. ORCID: 0000-0002-1270-8415, Banerjee, Dipanjan ORCID: 0000-0002-1933-8066, Brady, Sarah, Fox, Eoin ORCID: 0000-0003-1717-8641 and Lally, Caitríona ORCID: 0000-0003-4141-1685 (2019) Novel injectable gallium-based self-setting glass alginate hydrogel composite for cardiovascular tissue engineering. Carbohydrate Polymers, 217 . pp. 152-159. ISSN 0144-8617

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Abstract

Composite biomaterials offer a new approach for engineering novel, minimally-invasive scaffolds with properties that can be modified for a range of soft tissue applications. In this study, a new way of controlling the gelation of alginate hydrogels using Ga-based glass particles is presented. Through a comprehensive analysis, it was shown that the setting time, mechanical strength, stiffness and degradation properties of this composite can all be tailored for various applications. Specifically, the hydrogel generated through using a glass particle, wherein toxic aluminium is replaced with biocompatible gallium, exhibited enhanced properties. The material’s stiffness matches that of soft tissues, while it displays a slow and tuneable gelation rate, making it a suitable candidate for minimally-invasive intra-vascular injection. In addition, it was also found that this composite can be tailored to deliver ions into the local cellular environment without affecting platelet adhesion or compromising viability of vascular cells in vitro.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:glass; alginate; aneurysm; cardiovascular; polyalkenoate
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Publisher:Elsevier
Official URL:http://dx.doi.org/10.1016/j.carbpol.2019.04.016
Copyright Information:© 2019 Elsevier
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Enterprise Ireland Commercialization Fund (CF/2013/3364), Irish Research Council (PD/2011/2167), European Union Seventh Framework Programme, under the FP7-PEOPLE-2012-ITN (Marie Curie Actions, project No. 316973)
ID Code:23784
Deposited On:01 Oct 2019 11:46 by Thomas Murtagh . Last Modified 25 Jul 2022 13:20

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