On 25 January 2015, the fourth anniversary of the uprising that toppled Hosny Mubarak and brought the Muslim Brotherhood into power, Egyptian security forces arrested Aya Alaa Hosny in front of the Journalists Union in central Cairo. Aya is one of the spokeswomen and leader of the Women against the Coup (WAC), one of the most active women-only movements established by the Muslim Sisterhood following the Egyptian coup d’état in 2013. Since then, thousands of Islamist women and sympathisers have joined the Sisters in street demonstrations, human rights advocacy, and anti-regime protests, notwithstanding the high risk associated with political activism in a context of retrenched authoritarianism. This article offers a gendered analysis of the Egyptian Muslim Brotherhood by examining the activism of the Muslim Sisterhood, its female wing, post July 2013. Contrary to mainstream academic literature on Islamist women’s activism, which considers Islamist movements’ conservative gender ideology and sexual division of labour as an impediment to female political leadership, this study argues that Islamist informal networks can be conducive to female leadership under ‘negative’ political circumstances. As the case of the Muslim Sisterhood demonstrates, the repression of Islamists following the coup favoured the emergence of women’s leadership, firstly within women-only movements and subsequently, as the very survival of the MB became increasingly compromised, in the MB movement as a whole.