In recent years, the impact of immune function on muscle health has become apparent. The immune system has been identified as a key arbiter of muscle recovery and regeneration following injury or modified muscle use. The regulatory interactions between the immune system and muscle during regeneration are intricate and orchestrated by a plethora of innate and adaptive immune cell phenotypes. Principal among these are Macrophage. Briefly, damage to muscle drives a pro-inflammatory immune response. This response is characterised by the presence and activity of M1 polarised macrophage. M1 macrophage clears the site of injury and drive the proliferation of quiescent muscle progenitor cells. As healing progresses the immune microenvironment shifts, characterised by the increased prevalence of anti-inflammatory M2 macrophage, which promotes myoblast to myotube differentiation and quenches residual inflammation at the site of injury. Through ageing and lifestyle factors, inflammation can persist to become chronic, which detrimentally impacts the regenerative and metabolic functions of muscle tissue. Chronic inflammation in skeletal muscle is thought to increase lipid accumulation in muscle which further exacerbates the inflammatory response, which damages muscle tissue further resulting in a deleterious, degenerative loss of muscle mass and function overtime. Due to the role that macrophage have in regeneration, and the extent at which their dysfunction can impair muscle function, modulating macrophage activity may offer a potential therapeutic avenue to treat chronic muscle disease. Functional foods contain bioactive ingredients, that beneficially impact consumer health. This research highlights the potential application of immunomodulatory cow’s milk derived hydrolysates to promote muscle health through modulation of M1 and M2 macrophage phenotypes in vitro . We further identify that cow’s milk derived hydrolysates possess myomodulatory activity, able to promote glucoregulatory and anabolic pathways and promote wound healing in vitro . Additionally, this research also highlights the impact that modulated immune function has on key aspects of muscle function including glucose metabolism, protein anabolism and wound healing. Novel, food derived immunomodulators may provide an alternative, natural route for the treatment of inflammation induced muscle damage and metabolic implications