Cross-border cooperation on the island of Ireland has a long history, if often a limited scope. The emergence of statutory North/South bodies after the Belfast/Good Friday Agreement of 1998 added a new dynamic. This paper argues that the further development of the Dublin–Belfast Economic Corridor will require key stakeholders to engage widely, not only with a private sector whose rationale will be greater levels of commercial activity along the Corridor but also with others who will bring additional agendas into discussion, including sustainability and quality of life. Political engagement will also be critical to ensure that the top-down support, in terms of investment and alignment with other policy priorities, is present. The framework for this collaboration is already in place, something that was absent in the 1990s.