Skip to main content
DORAS
DCU Online Research Access Service
Login (DCU Staff Only)
The benefits and limitations of animal models for translational research in cartilage repair

Moran, Conor ORCID: 0000-0001-6808-5766, Ramesh, Ashwanth, Brama, Pieter A. J., O’Byrne, John M., O'Brien, Fergal J. ORCID: 0000-0003-2030-8005 and Levingstone, Tanya J. ORCID: 0000-0002-9751-2314 (2016) The benefits and limitations of animal models for translational research in cartilage repair. Journal of Experimental Orthopaedics, 3 . pp. 1196-1199. ISSN 2197-1153

Full text available as:

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Abstract

Much research is currently ongoing into new therapies for cartilage defect repair with new biomaterials frequently appearing which purport to have significant regenerative capacity. These biomaterials may be classified as medical devices, and as such must undergo rigorous testing before they are implanted in humans. A large part of this testing involves in vitro trials and biomechanical testing. However, in order to bridge the gap between the lab and the clinic, in vivo preclinical trials are required, and usually demanded by regulatory approval bodies. This review examines the in vivo models in current use for cartilage defect repair testing and the relevance of each in the context of generated results and applicability to bringing the device to clinical practice. Some of the preclinical models currently used include murine, leporine, ovine, caprine, porcine, canine, and equine models. Each of these has advantages and disadvantages in terms of animal husbandry, cartilage thickness, joint biomechanics and ethical and licencing issues. This review will examine the strengths and weaknesses of the various animal models currently in use in preclinical studies of cartilage repair.

Item Type:Article (Published)
Refereed:Yes
Additional Information:Article number:1 (2016)
Uncontrolled Keywords:Tissue engineering; Collagen, In vivo; Osteochondral; Cartilage
Subjects:Engineering > Biomedical engineering
Medical Sciences > Biomechanics
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Publisher:Springer Open
Official URL:https://dx.doi.org/10.1186/s40634-015-0037-x
Copyright Information:© 2015 The Authors. Open Access (CC-BY 4.0)
ID Code:27262
Deposited On:25 May 2022 14:37 by Thomas Murtagh . Last Modified 10 Jan 2023 15:04

Downloads

Downloads per month over past year

Archive Staff Only: edit this record

  • Student Email
  • Staff Email
  • Student Apps
  • Staff Apps
  • Loop
  • Disclaimer
  • Privacy
  • Contact Us