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Neuroergonomic assessment of developmental coordination disorder

Joshi, Shawn orcid logoORCID: 0000-0002-7938-6393, Weedon, Benjamin D. orcid logoORCID: 0000-0001-6983-5119, Esser, Patrick orcid logoORCID: 0000-0002-3227-0115, Liu, Yan‑Ci orcid logoORCID: 0000-0002-3194-259X, Springett, Daniella N. orcid logoORCID: 0000-0002-4478-827X, Meaney, Andy, Inacio, Mario, Delextrat, Anne orcid logoORCID: 0000-0003-0876-6775, Kemp, Steve, Ward, Tomás E. orcid logoORCID: 0000-0002-6173-6607, Izad, Hooshang, Dawes, Helen orcid logoORCID: 0000-0002-2933-5213 and Ayaz, Hasan orcid logoORCID: 0000-0001-5514-2741 (2022) Neuroergonomic assessment of developmental coordination disorder. Scientific Reports, 12 . ISSN 2045-2322

Until recently, neural assessments of gross motor coordination could not reliably handle active tasks, particularly in realistic environments, and offered a narrow understanding of motor‑cognition. By applying a comprehensive neuroergonomic approach using optical mobile neuroimaging, we probed the neural correlates of motor functioning in young people with Developmental Coordination Disorder (DCD), a motor‑learning deficit affecting 5–6% of children with lifelong complications. Neural recordings using fNIRS were collected during active ambulatory behavioral task execution from 37 Typically Developed and 48 DCD Children who performed cognitive and physical tasks in both single and dual conditions. This is the first of its kind study targeting regions of prefrontal cortical dysfunction for identification of neuropathophysiology for DCD during realistic motor tasks and is one of the largest neuroimaging study (across all modalities) involving DCD. We demonstrated that DCD is a motor‑cognitive disability, as gross motor /complex tasks revealed neuro‑hemodynamic deficits and dysfunction within the right middle and superior frontal gyri of the prefrontal cortex through functional near infrared spectroscopy. Furthermore, by incorporating behavioral performance, decreased neural efficiency in these regions were revealed in children with DCD, specifically during motor tasks. Lastly, we provide a framework, evaluating disorder impact in ecologically valid contexts to identify when and for whom interventional approaches are most needed and open the door for precision therapies.
Item Type:Article (Published)
Additional Information:Article number: 10239
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Computing
Research Institutes and Centres > INSIGHT Centre for Data Analytics
Publisher:Nature Research
Official URL:https://dx.doi.org/10.1038/s41598-022-13966-9
Copyright Information:© 2021 The Authors.
Funders:Action Medical Research, Chartered Society of Physiotherapy Charitable Trust (ref GN2445), CLEAR trust, Fulbright US-UK Fellowship, Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number F30HD103527, Allied Irish Banks, Science Foundation Ireland (Grant No. SFI/12/RC/2289_P2), Elizabeth Casson Trust and the NIHR Oxford Health Biomedical Research Centre
ID Code:27543
Deposited On:11 Aug 2022 17:14 by Thomas Murtagh . Last Modified 20 Apr 2023 17:08

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