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Reactive oxygen species (ROS), intimal thickening, and subclinical atherosclerotic disease

Burtenshaw, Denise orcid logoORCID: 0000-0002-5958-1773, Kitching, Michael orcid logoORCID: 0000-0002-9884-0790, Redmond, Eileen M. orcid logoORCID: 0000-0001-8642-4418, Megson, Ian L. orcid logoORCID: 0000-0001-8287-2459 and Cahill, Paul A. orcid logoORCID: 0000-0002-5385-6502 (2019) Reactive oxygen species (ROS), intimal thickening, and subclinical atherosclerotic disease. Frontiers in Cardiovascular Medicine, 6 . ISSN 2297-055X

Arteriosclerosis causes significant morbidity and mortality worldwide. Central to this process is the development of subclinical non-atherosclerotic intimal lesions before the appearance of pathologic intimal thickening and advanced atherosclerotic plaques. Intimal thickening is associated with several risk factors, including oxidative stress due to reactive oxygen species (ROS), inflammatory cytokines and lipid. The main ROS producing systems in-vivo are reduced nicotinamide dinucleotide phosphate (NADPH) oxidase (NOX). ROS effects are context specific. Exogenous ROS induces apoptosis and senescence, whereas intracellular ROS promotes stem cell differentiation, proliferation, and migration. Lineage tracing studies using murine models of subclinical atherosclerosis have revealed the contributory role of medial smooth muscle cells (SMCs), resident vascular stem cells, circulating bone-marrow progenitors and endothelial cells that undergo endothelial-mesenchymal-transition (EndMT). This review will address the putative physiological and patho-physiological roles of ROS in controlling vascular cell fate and ROS contribution to vascular regeneration and disease progression.
Item Type:Article (Published)
Uncontrolled Keywords:NOX; NAPDH oxidase; smooth muscle (physiology); endothelial cells; adventitial cells; stem cells; intimal thickening; arteriosclerosis
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Publisher:Frontiers Media
Official URL:https://doi.org/10.3389/fcvm.2019.00089
Copyright Information:© 2022 The Authors. Open Access (CC-BY 4.0)
Funders:Health Research Board of Ireland and European Union's INTERREG VA Programme, managed by the Special EU Programmes Body (SEUPB).
ID Code:27809
Deposited On:29 Sep 2022 12:34 by Thomas Murtagh . Last Modified 29 Sep 2022 12:34

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