Degryse, Bernard, Britto, Mishan, Shan, Chun Xu, Wallace, Robert G. 
ORCID: 0000-0002-1450-0634, Rochfort, Keith D. ORCID: 0000-0003-1198-5952, Cummins, Phil, Meade, Gerardene and Murphy, Ronan P.
(2017)
Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR.
Data in Brief, 15
.
pp. 600-605.
ISSN 2352-3409
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Abstract
The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively
| Item Type: | Article (Published) |
|---|---|
| Refereed: | Yes |
| Additional Information: | Supplementary data associated with this article can be found in the online version at http://dx.doi. org/10.1016/j.dib.2017.10.023 |
| Uncontrolled Keywords: | Urokinase receptor; Moesin; Merlin; Angiogenesis; siRNA |
| Subjects: | UNSPECIFIED |
| DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology |
| Publisher: | Elsevier |
| Official URL: | https://dx.doi.org/10.1016/j.dib.2017.10.023 |
| Copyright Information: | © 2017 The Authors. Open Access (CC BY 4.0) |
| Funders: | Irish Higher Education Authority Programme for Research in Third Level Institutes (HEAPRTLI Cycle 4: T3 Targeted Therapeutics & Theranostics), Health Research Board of Ireland (HRB-RP/2005/184, HRA/2009/122, HRA/2009/122/R), Science Foundation Ireland (SFI-04/BR/B0577, 11/TIDA/B1927) |
| ID Code: | 27866 |
| Deposited On: | 14 Oct 2022 15:38 by Thomas Murtagh . Last Modified 14 Oct 2022 15:38 |
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